Primer reporte de pseudogenes de enzimas SABATH de la vía metabólica de las xantinas en Ilex paraguariensis
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Ilex paraguariensis St. Hil. es un árbol dioico originario de las selvas subtropicales de América del Sur, cuyas hojas y pequeñas ramas son procesadas para preparar la infusión estimulante y popular conocida como “mate”. A partir de la exploración, desde el punto de vista transcriptómico, genómico y filogenético de la vía biosintética de las xantinas, pudo realizarse la detección de pseudogenes mediante el análisis comparativo con otras plantas de importancia agronómica. Se analizaron los transcriptos de I. paraguariensis utilizando como genoma de referencia el material elite desarrollado por el INTA EAA-Cerro Azul de Misiones y los datos aportados por el transcriptoma secuenciado por Debat et. al en 2014. Se realizó un examen filogenético de las enzimas de una gran familia de genes SABATH que catalizan la metilación de átomos de oxígeno de una amplia diversidad de ácidos carboxílicos. Los genes más recientemente evolucionados de la familia SABATH son los que corresponden a la vía Metiltransferasas de Xantina (XMT) y Cafeína Sintasa (CS). Investigando los diferentes tipos de metiltransferasas que presenta la yerba mate en el proceso metabólico de la conversión a cafeína, se categorizaron varias enzimas SABATH de los cuales tres correspondían a pseudogenes dentro del grupo de las cafeínas sintasa.
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Aceptado 2022-12-01
Publicado 2023-12-18
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